Proteomics

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Metaproteomics on preterm infant stool

ABSTRACT: Development of the gut microbiota is greatly impacted in preterm infants. Despite increasing knowledge about microbiota composition in preterm infants, knowledge about the functional signatures of the intestinal microbiota remains limited. The aim was to study transitions in microbiota activity during the first six postnatal weeks in ten preterm infants. A total of 64 stool samples were measured by LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Sjef Boeren  

PROVIDER: MSV000081616 | MassIVE | Tue Oct 17 07:49:00 BST 2017

SECONDARY ACCESSION(S): PXD005574

REPOSITORIES: MassIVE

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Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants.

Zwittink Romy D RD   van Zoeren-Grobben Diny D   Martin Rocio R   van Lingen Richard A RA   Groot Jebbink Liesbeth J LJ   Boeren Sjef S   Renes Ingrid B IB   van Elburg Ruurd M RM   Belzer Clara C   Knol Jan J  

Molecular & cellular proteomics : MCP 20170706 9

<h4>Objective</h4>Development of the gastrointestinal tract and immune system can be modulated by the gut microbiota. Establishment of the intestinal microbiota, in its turn, is affected by host and environmental factors. As such, development of the gut microbiota is greatly impacted in preterm infants, who have an immature gut and are exposed to factors like hospitalization, caesarean section, antibiotics, and respiratory support.<h4>Design</h4>We analyzed fecal microbiota composition and activ  ...[more]

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