Proteomics

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Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth


ABSTRACT: Preterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) before and after preterm birth. Using preterm pigs as model for preterm infants, we hypothesized that CA induces fetal and neonatal renal dysfunctions that can intially be detected via plasma proteome, partly explaining the frequent renal dysfunction in preterm infants. Fetal pigs (88% gestation) were given an IA dose of lipopolysaccharide (LPS, 1 mg/kg, n=28), delivered preterm by cesarean section three days later, and compared with controls (CON, n=26) at birth and postnatal day five. Plasma proteome and protein markers of inflammatory pathways were evaluated.

INSTRUMENT(S): Bruker BAF format

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Blood Plasma

SUBMITTER: Allan Stensballe  

LAB HEAD: Laboratory for Medical Mass spectrometry

PROVIDER: PXD014619 | Pride | 2021-03-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuanttxt_txt.zip Other
ProteomXchangeIDcodes.xlsx Xlsx
analysis01.baf Other
analysis01a.baf Other
analysis01b.baf Other
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Publications

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs.

Nguyen Duc Ninh DN   Thymann Thomas T   Goericke-Pesch Sandra K SK   Ren Shuqiang S   Wei Wei W   Skovgaard Kerstin K   Damborg Peter P   Brunse Anders A   van Gorp Charlotte C   Kramer Boris W BW   Wolfs Tim G TG   Sangild Per T PT  

The American journal of pathology 20181009 11


Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic immune status and organ functions. Preterm pigs exposed to IA lipopolysaccharide (LPS) for 3 days were compared with controls at birth and postnatal day 5 after formula feeding. IA LPS induced mild ch  ...[more]

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