Proteomics

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Chronic pancreatitis vs pancreatic cancer LC-MS


ABSTRACT: Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By radiology the evaluation of a pancreatic mass, i.e. the differential diagnosis between CP and PC is often difficult. Preoperative needle biopsies are difficult to obtain and are demanding to interpret. New blood based biomarkers are needed. The accuracy of the only established biomarker for PC, CA 19-9 is rather poor in differentiating between benign and malignant mass of the pancreas. In this study, we have performed mass spectrometry HDMSE analysis of serum samples from patients with chronic pancreatitis and pancreatic cancer. We have quantified 652 proteins and performed detailed statistical analysis such as principal component analysis, orthogonal partial least square discriminant analysis and receiver operating curve analysis.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Risto Renkonen  

PROVIDER: MSV000082883 | MassIVE | Fri Aug 31 22:22:00 BST 2018

SECONDARY ACCESSION(S): PXD005144

REPOSITORIES: MassIVE

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Publications

Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis.

Saraswat Mayank M   Joenväärä Sakari S   Seppänen Hanna H   Mustonen Harri H   Haglund Caj C   Renkonen Risto R  

Cancer medicine 20170601 7


Finland ranks sixth among the countries having highest incidence rate of pancreatic cancer with mortality roughly equaling incidence. The average age of diagnosis for pancreatic cancer is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis is 40-50 years, however, many cases overlap in age. By radiology, the evaluation of a pancreatic mass, that is, the differential diagnosis between chronic pancreatitis and pancreatic cancer is often difficult. Preoperative ne  ...[more]

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