Proteomics

Dataset Information

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Meant_RSK_BioID_2019

ABSTRACT: This dataset consists of 33 raw MS files and associated peak lists and result files, acquired on an Orbitrap Fusion Tribrid mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication by Antoine Meant et al. titled: RSK promotes p120-catenin phosphorylation and regulates cell-cell adhesion in melanoma. The manuscript defines the proximity interactome of RSK kinases and a new phosphorylation of p120catenin (CTNND1) and the consequences of this phosphorylation on CTNND1 proximity interactomes. Experiments are proximity-dependent biotinylation (BioID), all performed in biological triplicates with associated negative controls. Philippe Roux is the corresponding author of the manuscript philippe.roux at umontreal.ca. The manuscript is published in MCP: https://www.mcponline.org/content/early/2019/11/02/mcp.RA119.001811.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Philippe Roux  

PROVIDER: MSV000083414 | MassIVE | Thu Feb 07 10:34:00 GMT 2019

SECONDARY ACCESSION(S): PXD012619

REPOSITORIES: MassIVE

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Publications

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

Méant Antoine A   Gao Beichen B   Lavoie Geneviève G   Nourreddine Sami S   Jung Flora F   Aubert Léo L   Tcherkezian Joseph J   Gingras Anne-Claude AC   Roux Philippe P PP  

Molecular & cellular proteomics : MCP 20191102 1

The RAS/mitogen-activated protein kinase (MAPK) signaling pathway regulates various biological functions, including cell survival, proliferation and migration. This pathway is frequently deregulated in cancer, including melanoma, which is the most aggressive form of skin cancer. RSK (p90 ribosomal S6 kinase) is a MAPK-activated protein kinase required for melanoma growth and proliferation, but relatively little is known about its function and the nature of its cellular partners. In this study, w  ...[more]

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