Epichaperome and Hippocampal Stress
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ABSTRACT: Cellular and animal models and human specimens are used to show that in Alzheimer's disease, neuronal changes are mediated through pathologic chaperome networks, referred to as epichaperomes, leading to alterations in neuronal protein-protein connectivity and function. Epichaperome inhibition in cellular and mouse models of AD results in rebalance of synaptic protein networks, recovery of hippocampal LTP synaptic plasticity and cognitive function to wild-type levels. Our study uncovers cognitive deficits in AD that stem from an inability to encode new information because of aberrant neuronal protein-protein interaction networks.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Dr. Gabriela Chiosis
PROVIDER: MSV000083484 | MassIVE | Mon Feb 25 16:21:00 GMT 2019
REPOSITORIES: MassIVE
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