Proteomic changes in cuprizone induced remyelination and demyelination processes.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Velos Plus, Q Exactive
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Gabor Szilagyi
PROVIDER: MSV000083506 | MassIVE | Fri Mar 01 00:24:00 GMT 2019
REPOSITORIES: MassIVE
Publications
Proteomic changes during experimental de- and remyelination in the corpus callosum.
Szilagyi Gabor T GT Nawrocki Arkadiusz M AM Eros Krisztian K Schmidt Janos J Fekete Katalin K Elkjaer Maria L ML Hyrlov Kirsten H KH Larsen Martin R MR Illes Zsolt Z Gallyas Ferenc F
PloS one 20200409 4
<h4>Background</h4>In the cuprizone model of multiple sclerosis, de- and remyelination can be studied without major interference from the adaptive immune responses. Since previous proteomic studies did not focus on the corpus callosum, where cuprizone causes the most pronounced demyelination, we performed a bottom up proteomic analysis on this brain region.<h4>Methods</h4>Eight week-old mice treated with 0.2% cuprizone, for 4 weeks and controls (C) were sacrificed after termination of the treatm ...[more]
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