Dataset Information

Primary human natural killer cells retain proinflammatory IgG1 at the cell surface and express CD16a glycoforms with donor-dependent variability

ABSTRACT: Post-translational modification of NK cell CD16a and its IgG1 ligand

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Adam Barb

PROVIDER: MSV000083890 | MassIVE | Tue Jun 04 13:41:00 BST 2019

SECONDARY ACCESSION(S): PXD014127

REPOSITORIES: MassIVE

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Primary Human Natural Killer Cells Retain Proinflammatory IgG1 at the Cell Surface and Express CD16a Glycoforms with Donor-dependent Variability.

Patel Kashyap R KR Nott Joel D JD Barb Adam W AW

Molecular & cellular proteomics : MCP 20190829 11

Post-translational modification confers diverse functional properties to immune system proteins. The composition of serum proteins such as immunoglobulin G (IgG) strongly associates with disease including forms lacking a fucose modification of the crystallizable fragment (Fc) asparagine(N)-linked glycan that show increased effector function, however, virtually nothing is known about the composition of cell surface receptors or their bound ligands <i>in situ</i> because of low abundance in the ci ...[more]

PMID: 31467031

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