Dataset Information

Tissue architectural cues mediated by integrin signaling

ABSTRACT: Analysis of human or mouse tumor cell lines that target to different organs upon extravasation

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Lisa Jenkins

PROVIDER: MSV000084006 | MassIVE | Fri Jun 21 14:05:00 BST 2019

SECONDARY ACCESSION(S): PXD014345

REPOSITORIES: MassIVE

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Publications

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish.

Paul Colin D CD Bishop Kevin K Devine Alexus A Paine Elliott L EL Staunton Jack R JR Thomas Sarah M SM Thomas Joanna R JR Doyle Andrew D AD Miller Jenkins Lisa M LM Morgan Nicole Y NY Sood Raman R Tanner Kandice K

Cell systems 20190821 2

Tumor cells encounter a myriad of physical cues upon arrest and extravasation in capillary beds. Here, we examined the role of physical factors in non-random organ colonization using a zebrafish xenograft model. We observed a two-step process by which mammalian mammary tumor cells showed non-random organ colonization. Initial homing was driven by vessel architecture, where greater numbers of cells became arrested in the topographically disordered blood vessels of the caudal vascular plexus (CVP) ...[more]

PMID: 31445892

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