Time-Dependent Proteome Study: Human-in-mouse xenograft breast cancer tumor samples (0, 5, 30, 60 min)
Ontology highlight
ABSTRACT:
Ref: Mertins P et al., (2014) Mol Cell Proteomics, Apr 9. E-Publication
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap XL, LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Richard Smith Xian Chen Forest White Steven A. Carr Daniel C Liebler
PROVIDER: MSV000084260 | MassIVE | Fri Aug 30 03:47:00 BST 2019
SECONDARY ACCESSION(S): PXD015898
REPOSITORIES: MassIVE
Publications
Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels.
Mertins Philipp P Yang Feng F Liu Tao T Mani D R DR Petyuk Vladislav A VA Gillette Michael A MA Clauser Karl R KR Qiao Jana W JW Gritsenko Marina A MA Moore Ronald J RJ Levine Douglas A DA Townsend Reid R Erdmann-Gilmore Petra P Snider Jacqueline E JE Davies Sherri R SR Ruggles Kelly V KV Fenyo David D Kitchens R Thomas RT Li Shunqiang S Olvera Narciso N Dao Fanny F Rodriguez Henry H Chan Daniel W DW Liebler Daniel D White Forest F Rodland Karin D KD Mills Gordon B GB Smith Richard D RD Paulovich Amanda G AG Ellis Matthew M Carr Steven A SA
Molecular & cellular proteomics : MCP 20140409 7
Protein abundance and phosphorylation convey important information about pathway activity and molecular pathophysiology in diseases including cancer, providing biological insight, informing drug and diagnostic development, and guiding therapeutic intervention. Analyzed tissues are usually collected without tight regulation or documentation of ischemic time. To evaluate the impact of ischemia, we collected human ovarian tumor and breast cancer xenograft tissue without vascular interruption and pe ...[more]
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