Proteomics

Dataset Information

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Time-Dependent Proteome Study: Human ovarian cancer tumor samples (0, 5, 30, 60 min)


ABSTRACT:

The objective of the Time-Dependent Proteome Study, was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from patient-derived ovarian cancer tumors.
Ref: Mertins P et al., (2014) Mol Cell Proteomics, Apr 9. E-Publication
Ref: Gajadhar, A.S., et al., (2015) Cancer Res. Apr 1;75(7):1495-503. Epub 2015 Feb 10.

INSTRUMENT(S): LTQ Orbitrap XL, LTQ Velos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Richard Smith   Forest White  

PROVIDER: MSV000083107 | MassIVE | Mon Nov 05 18:07:00 GMT 2018

SECONDARY ACCESSION(S): PXD015899

REPOSITORIES: MassIVE

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Publications

Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels.

Mertins Philipp P   Yang Feng F   Liu Tao T   Mani D R DR   Petyuk Vladislav A VA   Gillette Michael A MA   Clauser Karl R KR   Qiao Jana W JW   Gritsenko Marina A MA   Moore Ronald J RJ   Levine Douglas A DA   Townsend Reid R   Erdmann-Gilmore Petra P   Snider Jacqueline E JE   Davies Sherri R SR   Ruggles Kelly V KV   Fenyo David D   Kitchens R Thomas RT   Li Shunqiang S   Olvera Narciso N   Dao Fanny F   Rodriguez Henry H   Chan Daniel W DW   Liebler Daniel D   White Forest F   Rodland Karin D KD   Mills Gordon B GB   Smith Richard D RD   Paulovich Amanda G AG   Ellis Matthew M   Carr Steven A SA  

Molecular & cellular proteomics : MCP 20140409 7


Protein abundance and phosphorylation convey important information about pathway activity and molecular pathophysiology in diseases including cancer, providing biological insight, informing drug and diagnostic development, and guiding therapeutic intervention. Analyzed tissues are usually collected without tight regulation or documentation of ischemic time. To evaluate the impact of ischemia, we collected human ovarian tumor and breast cancer xenograft tissue without vascular interruption and pe  ...[more]

Publication: 1/2

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