Ontology highlight
ABSTRACT: The objective of the Time-Dependent Proteome Study, was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from patient-derived ovarian cancer tumors.
Ref: Mertins P et al., (2014) Mol Cell Proteomics, Apr 9. E-Publication
Ref: Gajadhar, A.S., et al., (2015) Cancer Res. Apr 1;75(7):1495-503. Epub 2015 Feb 10.
INSTRUMENT(S): LTQ Orbitrap XL, LTQ Velos, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Richard Smith Forest White
PROVIDER: MSV000083107 | MassIVE | Mon Nov 05 18:07:00 GMT 2018
SECONDARY ACCESSION(S): PXD015899
REPOSITORIES: MassIVE
Mertins Philipp P Yang Feng F Liu Tao T Mani D R DR Petyuk Vladislav A VA Gillette Michael A MA Clauser Karl R KR Qiao Jana W JW Gritsenko Marina A MA Moore Ronald J RJ Levine Douglas A DA Townsend Reid R Erdmann-Gilmore Petra P Snider Jacqueline E JE Davies Sherri R SR Ruggles Kelly V KV Fenyo David D Kitchens R Thomas RT Li Shunqiang S Olvera Narciso N Dao Fanny F Rodriguez Henry H Chan Daniel W DW Liebler Daniel D White Forest F Rodland Karin D KD Mills Gordon B GB Smith Richard D RD Paulovich Amanda G AG Ellis Matthew M Carr Steven A SA
Molecular & cellular proteomics : MCP 20140409 7
Protein abundance and phosphorylation convey important information about pathway activity and molecular pathophysiology in diseases including cancer, providing biological insight, informing drug and diagnostic development, and guiding therapeutic intervention. Analyzed tissues are usually collected without tight regulation or documentation of ischemic time. To evaluate the impact of ischemia, we collected human ovarian tumor and breast cancer xenograft tissue without vascular interruption and pe ...[more]