MHtt tobacco roots proteome, QEHFX
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q-Exactive HF-X
ORGANISM(S): Nicotiana Tabacum (ncbitaxon:4097)
SUBMITTER: 
JiaHua Xie
PROVIDER: MSV000084557 | MassIVE | Thu Nov 07 21:34:00 GMT 2019
REPOSITORIES: MassIVE
Publications
A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR.
Hung Chiu-Yueh CY Zhu Chuanshu C Kittur Farooqahmed S FS He Maotao M Arning Erland E Zhang Jianhui J Johnson Asia J AJ Jawa Gurpreet S GS Thomas Michelle D MD Ding Tomas T TT Xie Jiahua J
Cellular and molecular life sciences : CMLS 20221017 11
Pathophysiology associated with Huntington's disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early pathophysiological events leading to HD still remains elusive. To gain new insights into the early polyQ-induced pathogenic events, we expressed Htt exon1 (Htt<sub>ex1</sub>) with a normal (21), or an extended (4 ...[more]
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