Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: David A. Dean
PROVIDER: MSV000084881 | MassIVE | Sun Feb 02 13:56:00 GMT 2020
REPOSITORIES: MassIVE
Bai Haiqing H Zhou Rui R Barravecchia Michael M Norman Rosemary R Friedman Alan A Yu Deborah D Lin Xin X Young Jennifer L JL Dean David A DA
JCI insight 20210222 4
An intact lung epithelial barrier is essential for lung homeostasis. The Na+, K+-ATPase (NKA), primarily serving as an ion transporter, also regulates epithelial barrier function via modulation of tight junctions. However, the underlying mechanism is not well understood. Here, we show that overexpression of the NKA β1 subunit upregulates the expression of tight junction proteins, leading to increased alveolar epithelial barrier function by an ion transport-independent mechanism. Using IP and mas ...[more]