Microbiota functional activity biosensors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Microbiota Mus Musculus
SUBMITTER: 
Richard J. Giannone Robert L. Hettich
PROVIDER: MSV000085341 | MassIVE | Mon Apr 27 09:48:00 BST 2020
REPOSITORIES: MassIVE
Publications
Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo.
Wesener Darryl A DA Beller Zachary W ZW Peters Samantha L SL Rajabi Amir A Dimartino Gianluca G Giannone Richard J RJ Hettich Robert L RL Gordon Jeffrey I JI
eLife 20210308
Methods for measuring gut microbiota biochemical activities in vivo are needed to characterize its functional states in health and disease. To illustrate one approach, an arabinan-containing polysaccharide was isolated from pea fiber, its structure defined, and forward genetic and proteomic analyses used to compare its effects, versus unfractionated pea fiber and sugar beet arabinan, on a human gut bacterial strain consortium in gnotobiotic mice. We produced 'Microbiota Functional Activity Biose ...[more]
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