Proteomics

Dataset Information

0

EDF1 coordinates cellular responses to ribosome collisions

ABSTRACT: Raw mass spectrometry data associated with the following paper: EDF1 coordinates cellular responses to ribosome collisions. Related to Figure 6B-6C, Figure 6-figure supplement 1 and Figure 6-source data 1. Files detail: Light-Polysome (12 BPRP fractions - labeled AO3310-3321); Heavy-Polysome (12 BPRP fractions - labeled AO3322-3333)

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: J. Wade Harper   Rachel Green   Eric J. Bennett  

PROVIDER: MSV000085420 | MassIVE | Fri May 15 19:19:00 BST 2020

SECONDARY ACCESSION(S): PXD019225

REPOSITORIES: MassIVE

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications

Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically identify proteins associated with collided ribosomes. This approach identified Endothelial differentiation-related factor 1 (EDF1) as a novel protein recruited to collided ribosomes during translational distress. Cryo-electron microscopic analyses of  ...[more]

Similar Datasets

Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085419 | MassIVE
Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085423 | MassIVE
Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085425 | MassIVE
Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085421 | MassIVE
Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085422 | MassIVE
Proteomics EDF1 coordinates cellular responses to ribosome collisions
2020-05-15 | MSV000085424 | MassIVE
Unknown EDF1 coordinates cellular responses to ribosome collisions.
| S-EPMC7486125 | biostudies-literature
Proteomics Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
2020-07-14 | PXD020239 | Pride
Transcriptomics EDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response
2020-08-02 | GSE149565 | GEO
Transcriptomics Edf1 control multiciliated ependymel cell associated genes expression
2023-12-31 | GSE244940 | GEO