Dataset Information

FBXO7 Binds to and Increases the Expression of the p105 Subunit of NF-kB

ABSTRACT: Cell lysate from HAP1 cells were separated on several columns, the proteins were digested with trypsin and analysed on a Q Exactive HF-X instrument.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Bertrand Fabre

PROVIDER: MSV000085912 | MassIVE | Wed Aug 05 05:56:00 BST 2020

SECONDARY ACCESSION(S): PXD020733

REPOSITORIES: MassIVE

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Publications

The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation.

Udasin Ronald G RG Gottfried Yossi Y Fabre Bertrand B Bercovich Beatrice B Ziv Tamar T Ciechanover Aaron A

Biochemical and biophysical research communications 20200912

The NF-κB transcription factor is involved in inflammation and cell proliferation, survival, and transformation. It is a heterodimer made of p50 or p52 and a member of the Rel family of proteins. p50 and p52 are derived from limited ubiquitin- and proteasome-mediated proteolytic processing of the larger precursors p105 and p100, respectively. Both precursors can be either processed or completely degraded by the ubiquitin-proteasome system. Previous work in our laboratory identified KPC1 as a ubi ...[more]

PMID: 32933748

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