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Dysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model

ABSTRACT: We hypothesize that alterations in the de novo proteome drive early metabolic alterations in the hippocampus that persist throughout AD progression. Using a combinatorial amino acid tagging approach to selectively label newly synthesized proteins, we found that the de novo proteome is disturbed in APP/PS1 mice prior to pathology development, affecting the synthesis of multiple components of the synaptic, lysosomal and mitochondrial pathways.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Thomas A. Neubert

PROVIDER: MSV000085962 | MassIVE | Mon Aug 17 08:57:00 BST 2020

REPOSITORIES: MassIVE

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