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High-throughput metabolomics predicts drug-target relationships for eukaryotic membrane proteins

ABSTRACT: Saccharomyces cerevisiae were treated with 1280 drugs from the Prestwick chemical library. Intracellular polar metabolite extracts were collected and measured in negative mode by flow injection analysis. In addition, intracellular metabolite extracts were collected and measured for inducible overexpression mutants in yeast membrane proteins.

INSTRUMENT(S): 6550 QTOF (Agilent)

ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932)

SUBMITTER: Uwe Sauer

PROVIDER: MSV000086451 | MassIVE | Fri Nov 13 02:45:00 GMT 2020

REPOSITORIES: MassIVE

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GNPS - High-throughput metabolomics predicts drug-target relationships for eukaryotic membrane proteins

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