Proteomics

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Malic enzyme 2 mediates fumarate signaling to regulate mitochondrial biogenesis


ABSTRACT: Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that coordinately activate for mitochondrial generation. Here, we report that Krebs cycle intermediate, fumarate, connects metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Proteomic profiling of ME2-interacting protein reveals that ME2 binds to mitoribosome proteins to regulate mitoribosome assembly and mtDNA-encoded protein production. ME2 also interacts with and modulates deoxyuridine 5-triphosphate nucleotidohydrolase activity to regulate thymidine generation and mtDNA abundance

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: David Scadden  

PROVIDER: MSV000086778 | MassIVE | Thu Jan 28 12:26:00 GMT 2021

SECONDARY ACCESSION(S): PXD023874

REPOSITORIES: MassIVE

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