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Effect of GP130 Antagonism on Microtubule Associated Proteins

ABSTRACT: TMT10plex analysis of microtubule associated proteins from right ventricular extracts of 3 control rats, 3 monocrotaline rats, and 4 monocrotaline rats treated with the GP130 antagonist SC144.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Kurt Prins

PROVIDER: MSV000087852 | MassIVE | Mon Jul 19 10:03:00 BST 2021

SECONDARY ACCESSION(S): PXD027422

REPOSITORIES: MassIVE

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Publications

Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility.

Prisco Sasha Z SZ Hartweck Lynn M LM Rose Lauren L Lima Patricia D A PDA Thenappan Thenappan T Archer Stephen L SL Prins Kurt W KW

Circulation. Heart failure 20211220 1

<h4>Background</h4>Right ventricular dysfunction (RVD) is the leading cause of death in pulmonary arterial hypertension (PAH), but no RV-specific therapy exists. We showed microtubule-mediated junctophilin-2 dysregulation (MT-JPH2 pathway) causes t-tubule disruption and RVD in rodent PAH, but the druggable regulators of this critical pathway are unknown. GP130 (glycoprotein 130) activation induces cardiomyocyte microtubule remodeling in vitro; however, the effects of GP130 signaling on the MT-JP ...[more]

PMID: 34923829

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