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Primary villous trophoblasts exposed to flame retardant BDE-47

ABSTRACT: We exposed primary villous trophoblasts to flame retardant BDE-47 (1, 5 uM) across three culture time points (15, 24, 39 hr).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Susan Fisher

PROVIDER: MSV000087870 | MassIVE | Fri Jul 23 00:01:00 BST 2021

REPOSITORIES: MassIVE

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Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS.

Chen Hao H Williams Katherine E KE Kwan Elaine Y EY Kapidzic Mirhan M Puckett Kenisha A KA San Ali A Fisher Susan J SJ Robinson Joshua F JF

Toxicology 20230628

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants and recognized developmental toxicants that are detectable in placental tissues. Higher levels of in utero PBDE exposure have been associated with an increased risk of adverse birth outcomes. During pregnancy, cytotrophoblasts (CTBs) from the placenta play critical roles in the formation of the maternal-fetal interface via uterine invasion and vascular remodeling. The differentiation of these cells towards an invas ...[more]

PMID: 37385330

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