Proteomics

Dataset Information

0

Spatial Venomics - Cobra Venom System Reveals Spatial Distinction of Snake Toxins by Mass Spectrometry Imaging


ABSTRACT: Despite extensive research, there is still limited knowledge of the functional biology of most animal toxins, including their venom production and storage, as well as the morphological structures within sophisticated venom producing tissues that might underpin venom modulation. Here we applied non-targeted mass spectrometry imaging (MSI), in combination with standard proteomic and transcriptomic approaches, to enable discrete toxin mapping in high-resolution intensity maps across a snake venom gland sourced from the Egyptian cobra (Naja haje). Matrix-assisted laser desorption/ionization (MALDI) MSI toxin visualization on the elapid venom gland reveals surprising spatial heterogeneity of different toxin classes at the proteoform level, which may be the result of physiological constraints on venom production and/or storage, or reflect the potential for venom modulation under different stimuli.

INSTRUMENT(S): impact II, rapifleX

ORGANISM(S): Naja Haje Haje (ncbitaxon:8642)

SUBMITTER: Benjamin-Florian Hempel  

PROVIDER: MSV000088427 | MassIVE | Mon Nov 22 03:36:00 GMT 2021

SECONDARY ACCESSION(S): PXD029870

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2015-01-08 | E-GEOD-53988 | biostudies-arrayexpress
2022-04-07 | GSE169217 | GEO
2015-01-08 | GSE53988 | GEO
2022-06-10 | PXD034174 | Pride
2016-05-18 | PXD003403 | Pride
2016-12-31 | GSE76257 | GEO
2024-08-29 | PXD048264 | Pride
2020-09-26 | GSE158565 | GEO
2022-02-23 | GSE197102 | GEO
2015-08-20 | PXD001726 | Pride