The Proteomic Characteristics of Rainbow Trout Blood with Severe, Moderate and Asymptomatic course of Vibrio anguillarum infection
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ABSTRACT: This data describes the clinical picture of natural Vibrio anguillarum infection in rainbow trout during an outbreak on a fish farm. Molecular mechanisms associated with the host immune response have been investigated using mass spectrometric analysis of trout plasma proteins. Three fish populations were identified among infected trout according to the severity of infection: fish with severe lesions (SL), with moderate infectious process (IP) and asymptomatic fish (AS). As expected, pro-inflammatory interleukins, complement components, acute phase proteins and antimicrobial peptides were implicated in the acute pathogenesis. Systemic coagulopathy was accompanied by increased antithrombotic reactions. Reconstruction of metabolic pathways also revealed a high energy requirement for the immune response in severely affected fish. An unexpected result was a small difference between fish with moderate symptoms and fish with no or minor external signs of pathology, proposed as resistant to infection. Increased production of antiproteases and enhanced blood coagulation cascade were observed in healthier fish, which may underlie the mechanisms of a controlled, non-self-damaging immune response to infection.
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Oncorhynchus Mykiss (ncbitaxon:8022)
SUBMITTER: Ekaterina V. Borvinskaya Stanislav R. Kurpe Irina V. Sukhovskaya
PROVIDER: MSV000088752 | MassIVE | Mon Jan 31 01:12:00 GMT 2022
SECONDARY ACCESSION(S): PXD031356
REPOSITORIES: MassIVE
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