Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q-Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Steven A. Carr
PROVIDER: MSV000089026 | MassIVE | Wed Mar 09 07:39:00 GMT 2022
REPOSITORIES: MassIVE
Cell 20220601 12
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we show that αS directly modulates processing bodies (P-bodies), membraneless organelles that function in mRNA turnover and storage. The N terminus of αS, but not other synucleins, dictates mutually exclusive binding either to cellular membranes or to P-bodies in the cytosol. αS associates with multiple decapping protei ...[more]