Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain, Neuron Of Cerebral Cortex
DISEASE(S): Parkinson's Disease
SUBMITTER: Virginie Redeker
LAB HEAD: Virginie Redeker; Ronald Melki
PROVIDER: PXD002257 | Pride | 2015-09-07
REPOSITORIES: Pride
Items per page: 1 - 5 of 18 |
The EMBO journal 20150831 19
Extracellular α-synuclein (α-syn) assemblies can be up-taken by neurons; however, their interaction with the plasma membrane and proteins has not been studied specifically. Here we demonstrate that α-syn assemblies form clusters within the plasma membrane of neurons. Using a proteomic-based approach, we identify the α3-subunit of Na+/K+-ATPase (NKA) as a cell surface partner of α-syn assemblies. The interaction strength depended on the state of α-syn, fibrils being the strongest, oligomers weak, ...[more]