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Multi-omics Characterization of Neutrophil Extracellular Trap Formation in Severe and Mild COVID-19 Infections

ABSTRACT: Analysis of human plasma from patients either infected or not infected with COVID-19

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Vincent R. Gerbasi

PROVIDER: MSV000089330 | MassIVE | Thu Apr 28 16:15:00 BST 2022

SECONDARY ACCESSION(S): PXD033558

REPOSITORIES: MassIVE

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Publications

Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections.

Bramer Lisa M LM Hontz Robert D RD Eisfeld Amie J AJ Sims Amy C AC Kim Young-Mo YM Stratton Kelly G KG Nicora Carrie D CD Gritsenko Marina A MA Schepmoes Athena A AA Akasaka Osamu O Koga Michiko M Tsutsumi Takeya T Nakamura Morio M Nakachi Ichiro I Baba Rie R Tateno Hiroki H Suzuki Shoji S Nakajima Hideaki H Kato Hideaki H Ishida Kazunari K Ishii Makoto M Uwamino Yoshifumi Y Mitamura Keiko K Paurus Vanessa L VL Nakayasu Ernesto S ES Attah Isaac K IK Letizia Andrew G AG Waters Katrina M KM Metz Thomas O TO Corson Karen K Kawaoka Yoshihiro Y Gerbasi Vincent R VR Yotsuyanagi Hiroshi H Iwatsuki-Horimoto Kiyoko K

Heliyon 20230307 3

The detailed mechanisms of COVID-19 infection pathology remain poorly understood. To improve our understanding of SARS-CoV-2 pathology, we performed a multi-omics and correlative analysis of an immunologically naïve SARS-CoV-2 clinical cohort from blood plasma of uninfected controls, mild, and severe infections. Consistent with previous observations, severe patient populations showed an elevation of pulmonary surfactant levels. Intriguingly, mild patients showed a statistically significant eleva ...[more]

PMID: 36915486

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