Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Geremy Clair
PROVIDER: MSV000089614 | MassIVE | Mon Jun 06 15:17:00 BST 2022
REPOSITORIES: MassIVE
Zhang Yue Y Bharathi Vanthana V Dokoshi Tatsuya T de Anda Jaime J Ursery Lauryn Tumey LT Kulkarni Nikhil N NN Nakamura Yoshiyuki Y Chen Jonathan J Luo Elizabeth W C EWC Wang Lamei L Xu Hua H Coady Alison A Zurich Raymond R Lee Michelle W MW Matsui Tsutomu T Lee HongKyu H Chan Liana C LC Schepmoes Athena A AA Lipton Mary S MS Zhao Rui R Adkins Joshua N JN Clair Geremy C GC Thurlow Lance R LR Schisler Jonathan C JC Wolfgang Matthew C MC Hagan Robert S RS Yeaman Michael R MR Weiss Thomas M TM Chen Xinhua X Li Melody M H MMH Nizet Victor V Antoniak Silvio S Mackman Nigel N Gallo Richard L RL Wong Gerard C L GCL
Proceedings of the National Academy of Sciences of the United States of America 20240202 6
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to the strong but ineffective inflammatory response that characterizes severe Coronavirus disease 2019 (COVID-19), with amplified immune activation in diverse cell types, including cells without angiotensin-converting enzyme 2 receptors necessary for infection. Proteolytic degradation of SARS-CoV-2 virions is a milestone in host viral clearance, but the impact of remnant viral peptide fragments from hi ...[more]