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Impact of different oral treatments on the composition of the supragingival plaque microbiome

ABSTRACT: Using a metaproteome approach in addition to a standard plaque-regrowth study, this study examined the impact of different concentrations of lactoperoxidase (LPO) in two lozenge formulations on early plaque formation, microbiome composition, and active biological processes in young orally healthy volunteers.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Prof. Uwe Voelker

PROVIDER: MSV000089755 | MassIVE | Wed Jun 29 06:25:00 BST 2022

REPOSITORIES: MassIVE

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Impact of different oral treatments on the composition of the supragingival plaque microbiome.

Rabe Alexander A Gesell Salazar Manuela M Michalik Stephan S Kocher Thomas T Below Harald H Völker Uwe U Welk Alexander A

Journal of oral microbiology 20221031 1

<h4>Background</h4>Dental plaque consists of a diverse microbial community embedded in a complex structure of exopolysaccharides. Dental biofilms form a natural barrier against pathogens but lead to oral diseases in a dysbiotic state.<h4>Objective</h4>Using a metaproteome approach combined with a standard plaque-regrowth study, this pilot study examined the impact of different concentrations of lactoperoxidase (LPO) on early plaque formation, and active biological processes.<h4>Design</h4>Sixtee ...[more]

PMID: 36338832

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