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Evaluation of Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics

ABSTRACT: The Orbitrap Ascend Tribrid mass spectrometer was systematically evaluated in the context of shotgun proteomics, and its performance was compared to that of the previous generation of Tribrid instrument - Orbitrap Eclipse

INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Ascend

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Joshua J. Coon

PROVIDER: MSV000091467 | MassIVE | Fri Mar 10 08:08:00 GMT 2023

REPOSITORIES: MassIVE

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Publications

Evaluation of the Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics.

He Yuchen Y Shishkova Evgenia E Peters-Clarke Trenton M TM Brademan Dain R DR Westphall Michael S MS Bergen David D Huang Jingjing J Huguet Romain R Senko Michael W MW Zabrouskov Vlad V McAlister Graeme C GC Coon Joshua J JJ

Analytical chemistry 20230630 28

Mass spectrometry (MS)-based proteomics is a powerful technology to globally profile protein abundances, activities, interactions, and modifications. The extreme complexity of proteomics samples, which often contain hundreds of thousands of analytes, necessitates continuous development of MS techniques and instrumentation to improve speed, sensitivity, precision, and accuracy, among other analytical characteristics. Here, we systematically evaluated the Orbitrap Ascend Tribrid mass spectrometer ...[more]

PMID: 37389810

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Deep Proteomic Compound Profiling with the Orbitrap Ascend Tribrid Mass Spectrometer Using Tandem Mass Tags and Real-Time Search

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C4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer

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| S-EPMC7295122 | biostudies-literature

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