Proteomics

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Dissecting detergent-insoluble proteome in Alzheimer's disease by improved TMT-MS of high accuracy


ABSTRACT: Protein aggregation of amyloid beta peptides and tau are pathological hallmarks of Alzheimer's disease (AD), which are often resistant to detergent extraction and thus enriched in the insoluble proteome. However, additional proteins that co-accumulate in the detergent-insoluble AD brain proteome remain less studied. Here we comprehensively characterized key proteins and pathways in the detergent-insoluble proteome from human AD brain samples by differential extraction, coupled with tandem mass tags labeling and two-dimensional liquid chromatography tandem mass spectrometry (TMT-LC/LC-MS/MS).

INSTRUMENT(S): Thermo Scientific Q-Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Junmin Peng  

PROVIDER: MSV000091796 | MassIVE | Tue Apr 25 15:47:00 BST 2023

REPOSITORIES: MassIVE

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