Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: Eric Dammer
LAB HEAD: Nicholas T. Seyfried
PROVIDER: PXD005321 | Pride | 2019-06-25
REPOSITORIES: pride
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ad_10110_e.mzXML | Mzxml |
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Proteomics 20161201 23
Despite a key role of amyloid-beta (Aβ) in Alzheimer's disease (AD), mechanisms that link Aβ plaques to tau neurofibrillary tangles and cognitive decline still remain poorly understood. The purpose of this study was to quantify proteins in the sarkosyl-insoluble brain proteome correlated with Aβ and tau insolubility in the asymptomatic phase of AD (AsymAD) and through mild cognitive impairment (MCI) and symptomatic AD. Employing label-free mass spectrometry-based proteomics, we quantified 2711 s ...[more]