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Human hypertrophic cardiomyopathy cardiac tissue phosphoproteomics

ABSTRACT: This study used TMT-pro method to look for phosphoproteomic differences in heart tissue of patients with hypertrophic cardiomyopathy and controls

INSTRUMENT(S): QExactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Michael Ackerman

PROVIDER: MSV000091822 | MassIVE | Fri Apr 28 23:16:00 BST 2023

REPOSITORIES: MassIVE

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Publications

Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy.

Garmany Ramin R Bos J Martijn JM Tester David J DJ Giudicessi John R JR Dos Remedios Cristobal G CG Dasari Surendra S Nagaraj Nagaswaroop K NK Nair Asha A AA Johnson Kenneth L KL Ryan Zachary C ZC Maleszewski Joseph J JJ Ommen Steve R SR Dearani Joseph A JA Ackerman Michael J MJ

Circulation. Genomic and precision medicine 20230220 2

<h4>Background</h4>Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not been fully elucidated. Their identification could serve as a nidus for the generation of novel therapeutics aimed at halting disease development or progression. Herein, we performed a comprehensive multi-omic characterization of hypertrophy pathways in HCM.<h4>Methods</h4>Flash-frozen cardiac tissues were collected from gen ...[more]

PMID: 36802768

Publication: 1/2

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miRNA expression profiles in the serum of cats with hypertrophic cardiomyopathy compared to healthy cats

Project description:MicroRNAs negatively regulate gene expression and may serve as biomarkers for human cardiomyopathy. In the domestic cat, hypertrophic cardiomyopathy (HCM) represents the most common primary cardiomyopathy. In humans, the etiology of HCM is linked to mutations in genes of contractile muscle proteins, while in cats a clear proof for causal mutations is missing. The etiology of feline HCM is uncertain. Diagnosis is made by heart ultrasound examination and measuring the serum level of N-terminal pro B-type natriuretic peptide. The purpose of this study was to investigate whether microRNA profiles in the serum of cats with HCM are different from the profiles of healthy cats and whether specific miRNAs can be detected to serve as potential biomarkers for feline HCM or may help in understanding the etiology of this disease Blood was drawn from two groups of cats: 12 healthy cats and 11 cats suffering from hypertrophic cardiomyopathy. After clotting, samples were centrifuged and total mRNA was extracted from serum. These 23 serum samples were analyzed and the groups were compared

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