Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: David MacMillan
PROVIDER: MSV000092043 | MassIVE | Fri May 26 13:54:00 BST 2023
REPOSITORIES: MassIVE
Huth Sean W SW Oakley James V JV Seath Ciaran P CP Geri Jacob B JB Trowbridge Aaron D AD Parker Dann L DL Rodriguez-Rivera Frances P FP Schwaid Adam G AG Ramil Carlo C Ryu Keun Ah KA White Cory H CH Fadeyi Olugbeminiyi O OO Oslund Rob C RC MacMillan David W C DWC
Journal of the American Chemical Society 20230720 30
The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. Elucidation of target binding regions is typically achieved by X-ray crystallography or photoaffinity labeling (PAL) approaches; yet, these methods present significant challenges. X-ray crystallography is a mainstay technique that has revolutionized drug discove ...[more]