Proteomics

Dataset Information

0

MicroMap photoproximity labeling enables small molecule binding site mapping


ABSTRACT: Proteomics data for MicroMap enabled binding site mapping

INSTRUMENT(S): timsTOF Pro 2

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: David MacMillan  

PROVIDER: MSV000092043 | MassIVE | Fri May 26 13:54:00 BST 2023

REPOSITORIES: MassIVE

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Publications


The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. Elucidation of target binding regions is typically achieved by X-ray crystallography or photoaffinity labeling (PAL) approaches; yet, these methods present significant challenges. X-ray crystallography is a mainstay technique that has revolutionized drug discove  ...[more]

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