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Chemical proteomics reveals the target landscape of 1,000 kinase inhibitor tool compounds

ABSTRACT: Here, we profiled the targets of 1,184 compounds from drug discovery projects in lysates of cancer cell lines using the Kinobeads approach. The resulting 500,000 compound-target interactions are available in ProteomicsDB and we exemplify how this molecular resource may be used for research. We anticipate that this molecular resource will aid drug discovery and chemical biology.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Bernhard Kuster

PROVIDER: MSV000092248 | MassIVE | Fri Jun 23 01:31:00 BST 2023

SECONDARY ACCESSION(S): PXD043230

REPOSITORIES: MassIVE

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