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Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model

ABSTRACT: 10-plex TMT dataset generated by immunoprecipitation of epitope-tagged COL2A1 constructs along with DSP-crosslinked interactors. This experiment allows for quantitative comparison of wild-type and Gly1170Ser COL2A1 interactomes in HT-1080 cells transiently transfected with COL2A1 under a constitutive promoter. Negative control samples are untransfected HT-1080 cells, used to identify high-confidence collagen-II interactors from non-specific binders.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Matthew Shoulders

PROVIDER: MSV000093517 | MassIVE | Tue Nov 28 05:55:00 GMT 2023

SECONDARY ACCESSION(S): PXD047329

REPOSITORIES: MassIVE

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Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in chondronoids

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