Evaluation of data-independent acquisition workflows for deep proteome coverage of EPS-urine

ABSTRACT: Here, we investigated the performance of DIA-MS on a cohort of urines collected from prostate cancer patients against DDA-MS. The performance of several commonly used DIA-MS analysis approaches were examined with our cohort-specific spectral libraries, library-free and a pan-human library. An enhanced prostate cancer urine spectral library was generated for improved proteomic coverage.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Thomas Kislinger  

PROVIDER: MSV000093759 | MassIVE | Wed Jan 03 12:29:00 GMT 2024

REPOSITORIES: MassIVE