Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase
SUBMITTER: Fengjie Huang
PROVIDER: MTBLS1259 | MetaboLights | 2021-11-18
REPOSITORIES: MetaboLights
Items per page: 1 - 5 of 20 |
Nature communications 20191031 1
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. Theabrownin increases the levels of ileal conjugated bile acids (BAs) which, in turn, inhibit the intestinal FXR-FGF15 signaling pathway, resulting in inc ...[more]