Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
SUBMITTER: Massimo Loda
PROVIDER: MTBLS135 | MetaboLights | 2019-08-22
REPOSITORIES: MetaboLights
Items per page: 5 1 - 5 of 16 |
Labbé David P DP Zadra Giorgia G Yang Meng M Reyes Jaime M JM Lin Charles Y CY Cacciatore Stefano S Ebot Ericka M EM Creech Amanda L AL Giunchi Francesca F Fiorentino Michelangelo M Elfandy Habiba H Syamala Sudeepa S Karoly Edward D ED Alshalalfa Mohammed M Erho Nicholas N Ross Ashley A Schaeffer Edward M EM Gibb Ewan A EA Takhar Mandeep M Den Robert B RB Lehrer Jonathan J Karnes R Jeffrey RJ Freedland Stephen J SJ Davicioni Elai E Spratt Daniel E DE Ellis Leigh L Jaffe Jacob D JD DʼAmico Anthony V AV Kantoff Philip W PW Bradner James E JE Mucci Lorelei A LA Chavarro Jorge E JE Loda Massimo M Brown Myles M
Nature communications 20190925 1
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading ...[more]