Dataset Information

Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development

ABSTRACT:

Exposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatography-tandem mass spectrometry approach was developed and validated. The assay enables the analysis of more than 80 highly-diverse xenobiotics in urine, serum/plasma and breast milk; with detection limits generally in the pg-ng mL-1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method's applicability for large-scale exposomics-type cohort studies.

INSTRUMENT(S): Liquid Chromatography MS - alternating - reverse phase

SUBMITTER: Mira Flasch

PROVIDER: MTBLS2442 | MetaboLights | 2023-10-26

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS2442	Other
	FILES	Other
	a_MTBLS2442_LC-MS_alternating_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS2442_LC-MS_alternating_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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Publications

Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development.

Jamnik Thomas T Flasch Mira M Braun Dominik D Fareed Yasmin Y Wasinger Daniel D Seki David D Berry David D Berger Angelika A Wisgrill Lukas L Warth Benedikt B

Nature communications 20220512 1

PMID: 35550507

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