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A Combined Metabolomic and Proteomic Investigation of the Effects of a Failure to Express Dystrophin in the Mouse Heart

ABSTRACT: Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism.

INSTRUMENT(S): INOVA

SUBMITTER: Jules Griffin

PROVIDER: MTBLS256 | MetaboLights | 2017-03-14

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS256	Other
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	a_MTBLS256_melaniekgulston_hnr_metabolite_profiling_NMR_spectroscopy.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS256_melaniekgulston_hnr_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv	Tabular

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Publications

A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart.

Gulston Melanie K MK Rubtsov Denis V DV Atherton Helen J HJ Clarke Kieran K Davies Kay E KE Lilley Kathryn S KS Griffin Julian L JL

Journal of proteome research 20080403 5

Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism. ...[more]

PMID: 18386883

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Model of heart failure induced by mild thiol-blocking with cystamine

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Microarray gene expression profiling of cardiac genes at the onset of heart failure

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