Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD018694
INSTRUMENT(S): Q Exactive
SUBMITTER: Javier Munoz
PROVIDER: MTBLS301 | MetaboLights | 2021-02-10
REPOSITORIES: MetaboLights
Items per page: 1 - 5 of 9 |
Nature communications 20210325 1
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimulates enhancers and, similar to 2i, stabilizes ESCs in the naïve state. Here, we use mass spectrometry to describe the molecular events (phosphoproteome, proteome, and metabolome) triggered by 2i and C ...[more]