Metabolomics

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Lipid mediators of inflammation in BALF 3-19 days after infection with influenza

ABSTRACT: In this study broncho-alveolar lavage fluid (BALF) from mice infected with influenza A virus, PR8 (200 PFU and 200,000 PFU), X31 (2000,000 PFU) was analyzed for lipidomic host response in comparison with the mock infected animals. Time Points: 3, 5, 7, 9, 11, 13, 19 days post infection, done in 8-10 replicates.)

INSTRUMENT(S): API 4000 QTRAP (AB Sciex)

SUBMITTER: Peter Askovich 

PROVIDER: MTBLS31 | MetaboLights | 2013-05-09

REPOSITORIES: MetaboLights

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Dataset's files

Source:
Action DRS
MTBLS31 Other
FILES Other
a_MTBLS31_balf_lipids_3-19_post_infection_with_influenza_a_test_metabolite_profiling_mass_spectrometry.txt Txt
i_Investigation.txt Txt
m_MTBLS31_balf_lipids_3-19_post_infection_with_influenza_a_test_metabolite_profiling_mass_spectrometry_v2_maf.tsv Tabular
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Publications

Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation.

Tam Vincent C VC   Quehenberger Oswald O   Oshansky Christine M CM   Suen Rosa R   Armando Aaron M AM   Treuting Piper M PM   Thomas Paul G PG   Dennis Edward A EA   Aderem Alan A  

Cell 20130701 1

Bioactive lipid mediators play a crucial role in the induction and resolution of inflammation. To elucidate their involvement during influenza infection, liquid chromatography/mass spectrometry lipidomic profiling of 141 lipid species was performed on a mouse influenza model using two viruses of significantly different pathogenicity. Infection by the low-pathogenicity strain X31/H3N2 induced a proinflammatory response followed by a distinct anti-inflammatory response; infection by the high-patho  ...[more]

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