Metabolomics

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Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis


ABSTRACT:

The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for early molecular characterization of patients followed by risk-stratified care. The main objective of this study was to evaluate the fluctuations of serum metabolomic profiles of COVID-19 patients with severe illness during the different disease stages in a longitudinal manner. We demonstrate a distinct metabolomic signature in serum samples of 32 hospitalized patients at the acute phase compared to the recovery period, suggesting the tryptophan (tryptophan, kynurenine and 3-hydroxy-DL-kynurenine) and arginine (citrulline and ornithine) metabolism as contributing pathways in the immune response to SARS-CoV-2 with a potential link to the clinical severity of the disease. In addition, we suggest that glutamine deprivation may further result in inhibited M2 macrophage polarization as a complementary process, and highlight the contribution of phenylalanine and tyrosine in the molecular mechanisms underlying the severe course of the infection. In conclusion, our results provide several functional metabolic markers for disease progression and severe outcome with potential clinical application.

INSTRUMENT(S): Liquid Chromatography MS -

SUBMITTER: Laura Ansone 

PROVIDER: MTBLS3852 | MetaboLights | 2022-08-23

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS3852 Other
FILES Other
a_MTBLS3852_LC-MS___metabolite_profiling.txt Txt
files-all.json Other
i_Investigation.txt Txt
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Publications

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis.

Ansone Laura L   Briviba Monta M   Silamikelis Ivars I   Terentjeva Anna A   Perkons Ingus I   Birzniece Liga L   Rovite Vita V   Rozentale Baiba B   Viksna Ludmila L   Kolesova Oksana O   Klavins Kristaps K   Klovins Janis J  

Microbiology spectrum 20211208 3


The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for early molecular characterization of patients followed by risk-stratified care. The main objective of this study was to evaluate the fluctuations of serum metabolomic profiles of COVID-19 patients with severe illness during the different disease stages in a longitudinal manner. We demonstrate a distinct metabolomic signature in serum samples of 32 hospitalized patients at the acute phase compared to the rec  ...[more]

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