Dataset Information

Automated, Parallel Mass Spectrometry Imaging and Structural Identification of Lipids

ABSTRACT: We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignment. This lipidome-per-pixel approach automatically identified and validated 104 unique molecular lipids and their spatial locations from rat cerebellar tissue.

SUBMITTER: Shane Ellis

PROVIDER: MTBLS597 | MetaboLights | 2018-05-21

REPOSITORIES: MetaboLights

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Automated, parallel mass spectrometry imaging and structural identification of lipids.

Ellis Shane R SR Paine Martin R L MRL Eijkel Gert B GB Pauling Josch K JK Husen Peter P Jervelund Mark W MW Hermansson Martin M Ejsing Christer S CS Heeren Ron M A RMA

Nature methods 20180521 7

We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignments. This lipidome-per-pixel approach automatically identified and validated 104 unique molecular lipids and their spatial locations from rat cerebellar tissue. ...[more]

PMID: 29786091

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			Action	DRS
	MTBLS597	Other
	FILES	Other
	a_MTBLS597_msms_standards.txt	Txt
	a_MTBLS597_neg_msi_minipig.txt	Txt
	a_MTBLS597_neg_msi_wistar.txt	Txt