Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - positive - hilic, Liquid Chromatography MS - negative - hilic
SUBMITTER: M. Wade Calcutt
PROVIDER: MTBLS607 | MetaboLights | 2021-04-06
REPOSITORIES: MetaboLights
Items per page: 1 - 5 of 20 |
Cell reports 20201201 11
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinated EIF5A (EIF5A<sup>Hyp</sup>) transports specific mRNAs to ribosomes for translation. We show that DHPS is induced in macrophages by two gastrointestinal pathogens, Helicobacter pylori and Citrobacter ...[more]