Metabolomics,Multiomics

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Impacts of the Callipyge mutation on ovine plasma metabolites

ABSTRACT: The ovine Callipyge mutation causes postnatal muscle hypertrophy localized to the pelvic limbs and torso, as well as body leanness. The mechanism underpinning enhanced muscle mass is unclear, as is the systemic impact of the mutation. To investigate potential systemic effects of the mutation, 1H NMR spectra of plasma taken from lambs at 8 and 12 weeks of age were measured. Multivariate statistical analysis of plasma metabolite profiles demonstrated effects of development and genotype but not gender. Plasma from Callipyge lambs at 12 weeks of age, but not 8 weeks, was characterized by a metabolic profile consistent with contributions from the affected hypertrophic fast twitch glycolytic muscle fibres. We conclude that there is an indirect systemic effect of the Callipyge mutation in skeletal muscle in the form of changes of blood metabolites, which may contribute to secondary phenotypes such as body leanness.

OTHER RELATED OMICS DATASETS IN: PRJNA251387

INSTRUMENT(S): Bruker

SUBMITTER: Juan Li 

PROVIDER: MTBLS77 | MetaboLights | 2015-01-31

REPOSITORIES: MetaboLights

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Dataset's files

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Action DRS
MTBLS77 Other
FILES Other
a_MTBLS77_callipygemutation_ovine_metabolite_profiling_NMR_spectroscopy.txt Txt
i_Investigation.txt Txt
m_MTBLS77_callipygemutation_ovine_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv Tabular
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Publications

Impacts of the Callipyge mutation on ovine plasma metabolites and muscle fibre type.

Li Juan J   Greenwood Paul L PL   Cockett Noelle E NE   Hadfield Tracy S TS   Vuocolo Tony T   Byrne Keren K   White Jason D JD   Tellam Ross L RL   Schirra Horst Joachim HJ  

PloS one 20140617 6

The ovine Callipyge mutation causes postnatal muscle hypertrophy localized to the pelvic limbs and torso, as well as body leanness. The mechanism underpinning enhanced muscle mass is unclear, as is the systemic impact of the mutation. Using muscle fibre typing immunohistochemistry, we confirmed muscle specific effects and demonstrated that affected muscles had greater prevalence and hypertrophy of type 2X fast twitch glycolytic fibres and decreased representation of types 1, 2C, 2A and/or 2AX fi  ...[more]

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