Dataset Information

The HuMet Repository: Watching human metabolism at work

ABSTRACT: Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.

INSTRUMENT(S): Q Exactive

SUBMITTER: Karsten Suhre

PROVIDER: MTBLS89 | MetaboLights | 1970-01-01

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS89	Other
	FILES	Other
	a_MTBLS89__NEG_1_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS89__NEG_2_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS89__POS_1_metabolite_profiling_mass_spectrometry.txt	Txt

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Publications

The HuMet Repository: Watching human metabolism at work.

Weinisch Patrick P Raffler Johannes J Römisch-Margl Werner W Arnold Matthias M Mohney Robert P RP Rist Manuela J MJ Prehn Cornelia C Skurk Thomas T Hauner Hans H Daniel Hannelore H Suhre Karsten K Kastenmüller Gabi G

Cell reports 20240720 8

Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web ap ...[more]

PMID: 39033506

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