Dataset Information
Complexome profiling to study consequences of membrane protein complexes in cells with knock down of ceramide synthase 4 and 5 in HCT-116 and Caco-2 cells.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Ilka Wittig
LAB HEAD: Sabine Grösch
PROVIDER: PXD030604 | Pride | 2025-01-07
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Data_Analysis_Caco.xlsx | Xlsx | |||
| Data_analysis_HCT116.xlsx | Xlsx | |||
| Gel_Caco.JPG | Other | |||
| Gel_HCT116.jpg | Other | |||
| P19_032_SabineGroesch_CerS4_10_01.raw | Raw |
Items per page: 1 - 5 of 259 |
Publications
Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome.
Biochimica et biophysica acta. Molecular basis of disease 20231004 1
Sphingolipids are important for the physicochemical properties of cellular membranes and deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and CerS5 are reduced which correlates with a reduced survival probability of late-stage colon cancer patients. Both enzymes are reduced after hypoxia in advanced colorectal cancer (CRC) cells (HCT-116, SW620) but not in non-metastatic CRC cells (SW480, Caco-2). Downregulation of CerS4 or CerS5 in advanced CRC cells enhanced tumor ...[more]
