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Omics score: 1063

Identification of altered metabolic pathways in Alzheimer's disease, mild cognitive impairment and cognitively normals using Metabolomics (CSF)

ABSTRACT: Criteria for the diagnosis of amnestic MCI included: (i) memory complaint documented by the patient and collateral source; (ii) impairment in 1 or more of the 4 cognitive domains (memory, executive functioning/attention, visuospatial, or language); (iii) essentially normal functional activities of daily living; and (iv) absence of dementia. In general, the amnestic MCI determination is made when the memory measures fall 1.0⿿1.5 SD below the means for age and education appropriate individuals in our community; however, rigid cutoffs on psychometric scores were not used to establish the diagnosis of amnestic MCI which was made on clinical grounds. The diagnosis of dementia was made using DSM-IV criteria, and the diagnosis of AD was made using established criteria. Subjects were considered to be CN if they performed within the normative range and did not meet criteria for MCI or dementia.

INSTRUMENT(S): TOF

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Alzheimers Disease

SUBMITTER: Ronald Petersen

PROVIDER: ST000047 | MetabolomicsWorkbench | Mon Mar 24 00:00:00 GMT 2014

REPOSITORIES: MetabolomicsWorkbench

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