Metabolomics

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Metabotypes of Subjects with Adverse Reactions Following Vaccination


ABSTRACT: Metabolomics may help identify a particular metabolic signature “metabotype” in patients who are predisposed to developing AEFI such as a systemic reaction, or myocarditis that currently is difficult or impossible to identify prior to the development of the AEFI. This proposed pilot study looks at the metabolic profiles of a specific population of subjects who received the smallpox vaccine with or without other concomitantly administered vaccines to help determine if a unique metabotype can be identified in subjects who reported systemic reactions following immunization. In addition, this proposed study will look at the metabolic profile of several subjects with subclinical or clinically diagnosed myopericarditis to determine if these subjects have a unique metabotype. The ability to identify a unique metabotype would allow a clinician to potentially mitigate serious AEFI and ultimately improve the quality of immunization healthcare. If identified, these profiles might represent novel biomarkers of risk that can supplement existing clinical decision making for risk stratification or vaccine exemptions.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

SUBMITTER: Susan Sumner  

PROVIDER: ST000440 | MetabolomicsWorkbench | Tue Aug 02 00:00:00 BST 2016

REPOSITORIES: MetabolomicsWorkbench

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