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Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging

ABSTRACT: Mammals display wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver of long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omic approach. We found that NMRs livers display a unique expression pattern of mitochondrial proteins that result in distinct metabolic features of their mitochondria. For instance, we observed a generally reduced respiration rate associated with lower protein levels of respiratory chain components, particularly complex I, and increased capacity to utilize fatty acids. Interestingly, we show that the same molecular networks are affected during aging in both NMR and humans, supporting a direct link to the extraordinary longevity of both species. Finally, we identified a novel longevity pathway and validated it experimentally in the nematode C. elegans.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Heterocephalus Glaber Cavia Porcellus (guinea Pig)

TISSUE(S): Liver

SUBMITTER: Joanna Kirkpatrick

LAB HEAD: Alessandro Ori

PROVIDER: PXD008720 | Pride | 2018-06-21

REPOSITORIES: Pride

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Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

Heinze Ivonne I Bens Martin M Calzia Enrico E Holtze Susanne S Dakhovnik Oleksandr O Sahm Arne A Kirkpatrick Joanna M JM Szafranski Karol K Romanov Natalie N Sama Sai Nagender SN Holzer Kerstin K Singer Stephan S Ermolaeva Maria M Platzer Matthias M Hildebrandt Thomas T Ori Alessandro A

BMC biology 20180802 1

<h4>Background</h4>Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the livers of young and old long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omics approach.<h4>Results</h4>We found that NMR livers display a unique expression pattern of mitochondrial ...[more]

PMID: 30068331

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